Glutathione-S-transferase-pi (GST-pi) expression in renal cell carcinoma

Christina Kaprilian, Maria Horti, Kosmas Kandilaris, Andreas Skolarikos, Nikolaos Trakas, Ioannis Kastriotis, Charalambos Deliveliotis

Abstract


Multidrug resistance correlates with unfavourable treatment outcomes in numerous cancers including renal cell carcinoma. The expression and clinical relevance of Glutathione-S-transferase-pi (GST-pi), a multidrug resistance factor, in kidney tumors remain controversial. We analyzed the expression of GST-pi in 60 formalin-fixed, paraffin-embedded renal cell carcinoma samples by immunohistochemistry and compared them with matched normal regions of the kidney. A significantly higher expression of GST-pi was observed in 87% of clear cell carcinoma and 50% of papillary subtypes. GST-pi expression did not correlate with tumor grade or patient survival. GST-pi is unlikely to be a prognostic factor for renal cell carcinoma. However, further studies with large number of samples are warranted to establish the role of GST-pi, if any, in intrinsic or acquired resistance of renal cell carcinoma to conventional treatments. 

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Keywords


Glutathione-s-transferase; GST-pi, immunohistochemistry, multidrug resistance, renal cell carcinoma

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DOI: http://dx.doi.org/10.15586/jkcvhl.2015.22

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Copyright (c) 2015 Christina Kaprilian, Maria Horti, Kosmas Kandilaris, Andreas Skolarikos, Nikolaos Trakas, Ioannis Kastriotis, Charalambos Deliveliotis

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