Exceptional Renal Metastasis from Adenoid Cystic Carcinoma of the Nasal Cavity and Literature Review

Main Article Content

Jihene Feki
Maissa Lajnef
Manel Mallouli
Kheireddine Ben mahfoudh
Tahia Boudawara
Afef Khanfir

Keywords

adenoid cystic, carcinoma, nasal cavity, kidney, renal metastases

Abstract

Adenoid cystic carcinoma (ACC) is a rare malignant cancer that arises from secretory glands. Slow growth, perineural invasion, and late recurrences are the main characteristics of ACC. Only few cases of kidney metastases from ACC have been reported in the literature. We report here the case of a 66-year-old female patient who presented with bilateral renal metastases from ACC of the nasal cavity, detected 14 years after treatment of primary tumor and 6 years after metastasectomy of lung metastases. Histological examination confirmed diagnosis and the patient was treated with systemic chemotherapy. Radiological evaluation showed stability of the disease. However, a progression with occurrence of metastases in other sites (lung and bones) has been observed after 7 months. She is still receiving second-line chemotherapy. To the best of our knowledge, this is the second case of kidney metastases from ACC of the nasal cavity.

Abstract 480 | PDF Downloads 562 HTML Downloads 68 XML Downloads 48

References

1. Bradley PJ. Adenoid cystic carcinoma of the head and neck: A review. Curr Opin Otolaryngol Head Neck Surg. 2004;12:127–32. 10.1097/00020840-200404000-00013

2. Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck–An update. Oral Oncol. 2015;51:652–61. 10.1016/j.oraloncology.2015.04.005

3. Dillon PM, Chakraborty S, Moskaluk CA, Joshi PJ, Thomas CY. Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck. 2016;38:620–627.

4. Khan AJ, DiGiovanna MP, Ross DA, Sasaki CT, Carter D, Son YH, et al. Adenoidcysticcarcinoma: A retrospective clinical review. Int J Cancer. 2001;96: 149–158. 10.1002/ijc.1013

5. Qiu DS, Xu LY, Hu XY. Imaging appearance of a singular metastatic adenoid cystic carcinoma of the right kidney: A case report and literature review. Oncol. Lett. 2014;8:2669–71. 10.3892/ol.2014.2546

6. Longo R, Jaud C, Gehin W, Hennequin L, Bastien C, Campitiello M, et al. Renal metastases from a nasal cavity mixed squamous cell and adenoid cystic carcinoma: A case report. Am J Case Rep. 8 Jan 2020;21:e919781-1–e919781-5. 10.12659/AJCR.919781