Impressive and Prolonged Response with Lenvatinib in a Highly Pretreated Patient with Metastatic Clear Cell Renal Cancer: A Case Report

Main Article Content

Sara Demurtas https://orcid.org/0000-0002-1559-3887
Mara Frascaroli https://orcid.org/0000-0002-7392-2909
Federico Sottotetti https://orcid.org/0000-0002-9679-6538
Alessandro Rametta
Giuseppe Procopio https://orcid.org/0000-0002-2498-402X
Laura Deborah Locati https://orcid.org/0000-0003-3315-2580

Keywords

case report, lenvatinib, renal cell carcinoma, tyrosine kinase inhibitor, VHL mutation

Abstract

Clear cell renal carcinoma (ccRCC) can occur in young people and could be associated with an aggressive behavior. While for the first-line treatment in metastatic disease, there is an agreement to rely on an immunotherapy (IO)-based combination regimen, no standard second-line regimens exist. Generally, tyrosine kinase inhibitors (TKIs) are employed, even in sequence, although no trials have demonstrated yet the best succession. Herein, we present the case of a 39-year-old male, with a very aggressive ccRCC with somatic VHL mutation and distant metastases at diagnosis. He was treated with four different lines of therapies, including TKIs, with progressive multiple tumor deposits. Lenvatinib alone as the fifth line was able to induce a remarkable and prolonged tumor shrinkage with manageable toxicities.

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