Journal of Kidney Cancer and VHL 2022-11-01T16:25:40+00:00 ​Dr. Ulka Vaishampayan Open Journal Systems <p>Journal of Kidney Cancer and VHL (ISSN: 2203-5826) is indexed in <strong>PubMed</strong>,&nbsp;Emerging Sources Citation Index&nbsp;of <strong>Web of Science</strong>, and the Directory of Open Access Journals (<strong>DOAJ</strong>). Journal is dedicated for the dissemination of research findings in kidney cancer and VHL.</p> A Case Report: Mucinous Tubular and Spindle Cell Carcinoma of Kidney with Spindle Cell Predominance Mimicking Mesenchymal Tumour 2022-01-11T12:38:34+00:00 Natarajan Ramya Murhekar Kanchan Raja Anand Sundersingh Shirley <p>Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is a rare variant of renal cell carcinoma which was first described in the 2004 World Health Organization classification of tumours of the kidney. Morphologically, MTSCC is composed of tubules merging with bland-appearing spindle cells in a myxoid/mucinous stroma. Diverse morphological patterns have been reported in MTSCC; however, a spindle cell predominant morphology mimicking a mesenchymal tumour is rare and only two cases have been reported so far. We report a case of MTSCC with spindle cell predominance in kidney which was a diagnostic challenge. Though MTSCC usually shows an indolent course, there have been cases showing aggressive behaviour even with bland morphology. Hence, a thorough histopathological evaluation with ancillary studies are required to differentiate spindle cell predominant MTSCC from its mimics. Our case was a 40-year-old female who was incidentally found to have a well-defined hypodense lesion measuring around 2 cm in the upper pole of the right kidney. Right partial nephrectomy was performed which showed a 2.7 × 2.5 × 2 cm well-defined grey tan tumour without necrosis or haemorrhage, limited to kidney. Histopathological examination showed sheets of bland-appearing spindle cells mimicking a mesenchymal tumour. The tumour was extensively sampled, revealing small foci of tubule formation and mucinous stroma. Tumour cells were positive for CK7, AMACR, and PAX8. A final diagnosis of MTSCC was made. Hereby, we discuss ways of differentiating MTSCC from other spindle cell tumours of the kidney.</p> 2022-10-31T00:00:00+00:00 Copyright (c) 2022 Ramya Natarajan, Murhekar Kanchan, Raja Anand, Sundersingh Shirley Mucinous Tubular and Spindle Cell Renal Cell Carcinoma (MTSC-RCC) with an Unusual Presentation in a Child 2022-04-28T18:56:28+00:00 Kanika Sharma Anjan Dhua Sandeep Agarwala Seema Kaushal <p>Mucinous tubular and spindle cell renal cell carcinoma (MTSC-RCC) is a rare but favorable variant of renal cell carcinoma, predominantly found in adults. Complete surgical excision is the treatment of choice. We are reporting an intriguing case of bilateral MTSC-RCC in a 13-year-old-boy with rapid disease progression, leading to metastatic disease and subsequent demise of the child.</p> 2022-10-29T00:00:00+00:00 Copyright (c) 2022 Kanika Sharma, Anjan Dhua, Sandeep Agarwala, Seema Kaushal Partial Nephrectomy for T1b/T2 Renal Mass: An Added Shift from Radical Nephrectomy 2022-08-26T17:50:41+00:00 Mohamed Sharafeldeen Wael Sameh Vahid Mehrnoush Amer Alaref Radu Rozenberg Asmaa Ismail Hazem Elmansy Walid Shahrour Ahmed Zakaria Osama Elmeslemany Nishigandha Burute Anatoly Shuster Owen Prowse Ahmed Kotb <p>The aim of our study was to show our short-term experience in managing large renal masses (cT1b/T2) through partial nephrectomy (PN) over the last 3 years. Retrospective data collection for all patients managed by PN for renal masses larger than 4 cm over the last 3 years. Epidemiological data were collected. Surgical data including surgical and ischemic times as well as intra and postoperative complications were collected. Pre- and postoperative estimated glomerular filtration rate (eGFR) data were collected and correlated as well as postoperative complications and recurrence. We could identify 47 patients managed by PN for radiologically confirmed &gt;4 cm renal masses. The mean age of the patients was 55.7 ± 13.4, including 29 males and 18 females. Masses were T1b and T2 in 40 and 7 patients, respectively. The mean tumor size was 6.2 ± 1.5 cm. Using renal nephrometry score; 8, 28, and 11 had low, moderate, and high complexity, respectively. Renal cell carcinoma (RCC) was identified in 42 patients. Five patients out of 42 cancerous cases (12%) had pathological T3 RCC. The mean preoperative and postoperative eGFR were 89.09 ± 12.41 and 88.50 ± 10.50, respectively (P 0.2). The median follow-up was 14 months and within that short time, no patient had evidence for cancer recurrence. PN for large renal masses is safe in experienced hands and should be attempted in a higher percentage of patients, regardless of the tumor complexity. No cancer recurrence or deterioration of renal function was observed within our short-term follow-up.</p> 2022-10-06T00:00:00+00:00 Copyright (c) 2022 Mohamed Sharafeldeen, Wael Sameh, Vahid Mehrnoush, Amer Alaref, Radu Rozenberg, Asmaa Ismail, Hazem Elmansy, Walid Shahrour, Ahmed Zakaria, Osama Elmeslemany, Nishigandha Burute, Anatoly Shuster, Owen Prowse, Ahmed Kotb