Nivolumab in Renal Cell Carcinoma: Current Trends and Future Perspectives
Main Article Content
Keywords
checkpoint inhibitors, immunotherapy, nivolumab, renal cell carcinoma, targeted therapy
Abstract
Targeted agents form the backbone of most therapeutic strategies in advanced renal cell carcinoma (aRCC) but ultimately resistance develops and toxicity often leads to discontinuation of treatment, limiting the clinical benefits of these treatments. Nivolumab, a fully human IgG4 anti-PD-1 antibody, selectively blocks the interaction between PD-1 and its ligands PD-L1 and PD-L2 and provides a novel therapy option for patients with aRCC. In 2015, the pivotal phase III study CheckMate 025 led to the Food and Drug Administration approval of nivolumab in patients with aRCC who had received prior anti-angiogenic therapy, and in 2017, the phase III study CheckMate 214 showed that combined immunotherapy with nivolumab plus ipilimumab resulted in greater objective response rate and prolonged progression-free survival when compared with sunitinib in intermediate- and poor-risk patients with previously untreated aRCC. Early studies of nivolumab in association with anti-angiogenic therapy have generated enthusiasm and multiple combination trials are ongoing.
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25. Xu KY, Wu S. Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma. Biomark Res. 2015;3:5. http://dx.doi.org/10.1186/s40364-015-0030-7
26. Opdivo (nivolumab) injection [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Co.; 2016.
27. Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91. http://dx.doi.org/10.1093/annonc/mdv383
28. Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, et al. Nivolumab for metastatic renal cell carcinoma: Results of a randomized phase II trial. J Clin Oncol. 2015;33(13):1430–7. http://dx.doi.org/10.1200/JCO.2014.59.0703
29. Escudier B, Tannir NM, McDermott DF, et al. CheckMate 214: Efficacy and safety of nivolumab plus ipilimumab vs sunitinib for treatment-naive advance or metastatic renal cell carcinoma, including IMDC risk and PD-L1 expression subgroups. Presented at 2017 ESMO Congress; Madrid, Spain; September 8–12, 2017. Abstract LBA5.
30. Amin A, Plimack E, Infante J, Ernstoff M, Rini B, McDermot D, et al. Nivolumab in combination with sunitinib or pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2014;32:abstract 5010.
2. Xu JX, Maher VE, Zhang L, Tang S, Sridhara R, Ibrahim A, et al. FDA approval summary: Nivolumab in advanced renal cell carcinoma after anti-angiogenic therapy and exploratory predictive biomarker analysis. Oncologist. 2017;22(3):311–317. http://dx.doi.org/10.1634/theoncologist.2016-0476
3. Gianchecchi E, Delfino DV, Fierabracci A. Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity. Autoimmun Rev. 2013;12(11):1091–100. http://dx.doi.org/10.1016/j.autrev.2013.05.003
4. Decker WK, Safdar A. Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley’s legacy revisited. Cytokine Growth Factor Rev. 2009;20(4):271–81. http://dx.doi.org/10.1016/j.cytogfr.2009.07.004
5. Yagoda A, Bander NH. Failure of cytotoxic chemotherapy, 1983–1988, and the emerging role of monoclonal antibodies for renal cancer. Urol Int. 1989;44(6):338–45. http://dx.doi.org/10.1159/000281537
6. Porta C, Bonomi L, Lillaz B, Paglino C, Rovati B, Imarisio I, et al. Renal cell carcinoma-induced immunosuppression: An immunophenotypic study of lymphocyte subpopulations and circulating dendritic cells. Anticancer Res. 2007;27(1A):165–73.
7. Kroemer G, Andreu JL, Gonzalo JA, Gutierrez-Ramos JC, Martínez C. Interleukin-2, autotolerance, and autoimmunity. Adv Immunol. 1991;50:147–235. http://dx.doi.org/10.1016/S0065-2776(08)60825-1
8. Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med. 1985;313(23):1485–92. http://dx.doi.org/10.1056/NEJM198512053132327
9. Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol. 1995;13(3):688–96. http://dx.doi.org/10.1200/JCO.1995.13.3.688
10. Fisher RI, Rosenberg SA, Fyfe G. Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J Sci Am. 2000;6(Suppl 1):S55–7.
11. Yang JC, Sherry RM, Steinberg SM, Topalian SL, Schwartzentruber DJ, Hwu P, et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol. 2003;21(16):3127–32. http://dx.doi.org/10.1200/JCO.2003.02.122
12. McDermott DF, Regan MM, Clark JI, Flaherty LE, Weiss GR, Logan TF, et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol. 2005;23(1):133–41. http://dx.doi.org/10.1200/JCO.2005.03.206
13. Dutcher JP, Schwartzentruber DJ, Kaufman HL, Agarwala SS, Tarhini AA, Lowder JN, et al. High dose interleukin-2 (Aldesleukin) – Expert consensus on best management practices-2014. J Immunother Cancer. 2014;2:26. http://dx.doi.org/10.1186/s40425-014-0026-0
14. Quesada JR, Swanson DA, Trindade A, Gutterman JU. Renal cell carcinoma: Antitumor effects of leukocyte interferon. Cancer Res. 1983;43(2):940–7.
15. Logan JE, Rampersaud EN, Sonn GA, Chamie K, Belldegrun AS, Pantuck AJ, et al. Systemic therapy for metastatic renal cell carcinoma: A review and update. Rev Urol. 2012;14(3–4):65–78.
16. Coppin C, Porzsolt F, Awa A, Kumpf J, Coldman A, Wilt T. Immunotherapy for advanced renal cell cancer. Cochrane Database Syst Rev. 2005;(1):CD001425.
17. Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372(9637):449–56. http://dx.doi.org/10.1016/S0140-6736(08)61039-9
18. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115–24. http://dx.doi.org/10.1056/NEJMoa065044
19. Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125–34. http://dx.doi.org/10.1056/NEJMoa060655
20. Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol. 2010;28(6):1061–8. http://dx.doi.org/10.1200/JCO.2009.23.9764
21. Rini BI, Atkins MB. Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol. 2009;10(10):992–1000. http://dx.doi.org/10.1016/S1470-2045(09)70240-2
22. Brahmer JR, Hammers H, Lipson EJ. Nivolumab: Targeting PD-1 to bolster antitumor immunity. Future Oncol. 2015;11(9):1307–26. http://dx.doi.org/10.2217/fon.15.52
23. Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373(19):1803–13. http://dx.doi.org/10.1056/NEJMoa1510665
24. Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54. http://dx.doi.org/10.1056/NEJMoa1200690
25. Xu KY, Wu S. Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma. Biomark Res. 2015;3:5. http://dx.doi.org/10.1186/s40364-015-0030-7
26. Opdivo (nivolumab) injection [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Co.; 2016.
27. Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91. http://dx.doi.org/10.1093/annonc/mdv383
28. Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, et al. Nivolumab for metastatic renal cell carcinoma: Results of a randomized phase II trial. J Clin Oncol. 2015;33(13):1430–7. http://dx.doi.org/10.1200/JCO.2014.59.0703
29. Escudier B, Tannir NM, McDermott DF, et al. CheckMate 214: Efficacy and safety of nivolumab plus ipilimumab vs sunitinib for treatment-naive advance or metastatic renal cell carcinoma, including IMDC risk and PD-L1 expression subgroups. Presented at 2017 ESMO Congress; Madrid, Spain; September 8–12, 2017. Abstract LBA5.
30. Amin A, Plimack E, Infante J, Ernstoff M, Rini B, McDermot D, et al. Nivolumab in combination with sunitinib or pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2014;32:abstract 5010.
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Feb 6, 2018
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Nivolumab in Renal Cell Carcinoma: Current Trends and Future Perspectives. (2018). Journal of Kidney Cancer, 5(1), 15-18. https://doi.org/10.15586/jkcvhl.2018.102
Section
Kidney Cancer: Review Articles
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How to Cite
Nivolumab in Renal Cell Carcinoma: Current Trends and Future Perspectives. (2018). Journal of Kidney Cancer, 5(1), 15-18. https://doi.org/10.15586/jkcvhl.2018.102