Renal Cell Carcinoma with Cardiac Metastases: A Case Report and Review of the Literature
Main Article Content
Keywords
cardiac mass, clear cell, metastatic renal cell carcinoma, renal cell carcinoma, systemic therapy
Abstract
Cardiac metastases from renal cell carcinoma (RCC) are very rare. We describe the case of a woman with RCC with cardiac metastases involving the entire right atrium, penetrating through the myocardium, with extension into the tricuspid valve and right ventricle. This report highlights the unique challenge of the diagnosis and treatment of cardiac metastases in RCC.
References
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24. Khetani VV, Portal DE, Shah MR, Mayer T, Singer EA. Combination drug regimens for metastatic clear cell renal cell carcinoma. World J Clin Oncol. 2020;11(8):541–562. 10.5306/wjco.v11.i8.541
25. Doppalapudi SK, Leopold ZR, Thaper A, Kaldany A, Chua K, Patel HV, et al. Clearing up clear cell: Clarifying the immuno-oncology treatment landscape for metastatic clear cell RCC. Cancers (Basel). 2021;13(16) 4140. 10.3390/cancers13164140
26. Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer. 2008;113(1):78–83. 10.1002/cncr.23518
27. Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, et al. Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 2021;384(9):829–841. 10.1056/NEJMoa2026982
28. Yuen A, Crandall B. Cardiovascular effects of tyrosine kinase inhibitors in patients with advanced renal cell carcinoma at the VA Sa n Diego healthcare system. Fed Pract. 2019;36(Suppl 3):S18–S24.
29. Ansari J, Alhelali S, Albinmousa Z, Farrag A, Ali AM, Abdelgelil M, et al. Rare case of intracardiac renal cell carcinoma metastasis with response to nivolumab: Case report and literature review. Case Rep Oncol. 2018;11(3):861–870. 10.1159/000495459
30. Cheng H, Force T. Why do kinase inhibitors cause cardiotoxicity and what can be done about it? Prog Cardiovasc Dis. 2010;53(2):114–120. 10.1016/j.pcad.2010.06.006
31. Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, et al. Efficacy and safety of nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma. Clin Cancer Res. 2021;27(1):78–86. 10.1158/1078-0432.CCR-20-2063
2. Decastro GJ, McKiernan JM. Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol Clin North Am. 2008;35(4):581–592; vi. 10.1016/j.ucl.2008.07.005
3. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. 10.3322/caac.21708
4. Garnick MB. Primary neoplasms of the kidney. In: Wilcox CS, editor. Therapy in nephrology and hypertension: A companion to Brenner and Rector’s the kidney. Philadelphia, PA: WB Saunders; 337–40. 1998.
5. Padala SA, Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, et al. Epidemiology of renal cell carcinoma. World J Oncol. 2020;11(3):79–87. 10.14740/wjon1279
6. Schmidt AL, Tabakin AL, Singer EA, Choueiri TK, McKay RR. Next steps: Sequencing therapies in metastatic kidney cancer in the contemporary era. Am Soc Clin Oncol Educ Book. 2021;41:1–11. 10.1200/EDBK_320785
7. Geynisman DM, Maranchie JK, Ball MW, Bratslavsky G, Singer EA. A 25 year perspective on the evolution and advances in an understanding of the biology, evaluation and treatment of kidney cancer. Urol Oncol. 2021;39(9):548–560. 10.1016/j.urolonc.2021.04.038
8. Tabakin AL, Stein MN, Anderson CB, Drake CG, Singer EA. Cytoreductive nephrectomy for metastatic renal cell carcinoma, the ultimate urologic “Choosing Wisely” campaign: A narrative review. Transl Cancer Res. 2020;9(11):7337–7349. 10.21037/tcr-20-2343
9. Patel HV, Shinder B, Srinivasan R, Singer EA. Challenges and opportunities in the management of metastatic renal cell carcinoma: Combination therapy and the role of cytoreductive surgery. Curr Opin Oncol. 2020;32(3):240–249. 10.1097/CCO.0000000000000621
10. Bazine A, Fetohi M, Tanz R, Mahfoud T, Ichou M, Errihani H. Cardiac metastases of renal cell carcinoma revealed by syncope: Diagnosis and treatment. Case Rep Oncol. 2014;7(2):560–564. 10.1159/000366292
11. Alghamdi A, Tam J. Cardiac metastasis from a renal cell carcinoma. Can J Cardiol. 2006;22(14):1231–1232. 10.1016/S0828-282X(06)70964-3
12. Zustovich F, Gottardo F, De Zorzi L, Cecchetto A, Dal Bianco M, Mauro E, et al. Cardiac metastasis from renal cell carcinoma without inferior vena involvement: A review of the literature based on a case report. Two different patterns of spread? Int J Clin Oncol. 2008;13(3):271–274. 10.1007/s10147-007-0730-6
13. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: A review of case reports. J Med Case Rep. 2011;5:429. 10.1186/1752-1947-5-429
14. Goldberg AD, Blankstein R, Padera RF. Tumors metastatic to the heart. Circulation. 2013;128(16):1790–1794. 10.1161/CIRCULATIONAHA.112.000790
15. Campisi A, Ciarrocchi AP, Asadi N, Dell’Amore A. Primary and secondary cardiac tumors: Clinical presentation, diagnosis, surgical treatment, and results. Gen Thorac Cardiovasc Surg. 2022;70(2):107–115. 10.1007/s11748-021-01754-7
16. Stellato M, Cursano MC, Citarella F, Pantano D, Russano M, Dell’ Aquila E, et al. Response to cabozantinib in renal cell carcinoma with cardiac metastases. Anticancer Drugs. 2020;31(3):314–318. 10.1097/CAD.0000000000000889
17. Barajas-Ochoa A, Suero-Abreu GA. Cardiac metastases from renal cell carcinoma. J Gen Intern Med. 2020;35(12):3711–3712. 10.1007/s11606-020-06200-7
18. Zhang B, Malouf J, Young P, Kohli M, Dronca R. Cardiac metastasis in renal cell carcinoma without vena cava or atrial involvement: An unusual presentation of metastatic disease. Rare Tumors. 2013;5(3):e29. 10.4081/rt.2013.e29
19. Li Fraine S, Coman D, Durand M, Laskine M. Renal cell carcinoma with cardiac metastases. World J Oncol. 2021;12(4):124–126. 10.14740/wjon1376
20. Usman RM, Yahya O, Marella HK, Jain AL, Peravali R, Premkumar R, et al. Renal cell carcinoma presenting with combined cervical lymphadenopathy and cardiac metastasis without inferior vena cava involvement. WMJ. 2021;120(2):142–144.
21. Nkengurutse G, Wang Q, Tian F, Jiang S, Zhang L, Sun W. Renal cell carcinoma metastasizing to left atrium with coronary sinus invasion: A rare site of metastasis mimicking myxoma. Front Oncol. 2019;9:738. 10.3389/fonc.2019.00738
22. Schinzari G, Monterisi S, Signorelli D, Cona MS, Cassano A, Danza F, et al. Cardiac metastasis from renal cell carcinoma successfully treated with pazopanib: Impact of TKIs’ antiangiogenic activity. Tumori. 2014;100(6):e298–300. 10.1177/1778.19304
23. Miura S, Yamada A, Iba Y, Maruyama R, Hatta E, Kurimoto Y. Surgical treatment of isolated right ventricular metastasis from renal cell carcinoma. Surg Case Rep. 2019;5(1):162. 10.1186/s40792-019-0733-3
24. Khetani VV, Portal DE, Shah MR, Mayer T, Singer EA. Combination drug regimens for metastatic clear cell renal cell carcinoma. World J Clin Oncol. 2020;11(8):541–562. 10.5306/wjco.v11.i8.541
25. Doppalapudi SK, Leopold ZR, Thaper A, Kaldany A, Chua K, Patel HV, et al. Clearing up clear cell: Clarifying the immuno-oncology treatment landscape for metastatic clear cell RCC. Cancers (Basel). 2021;13(16) 4140. 10.3390/cancers13164140
26. Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer. 2008;113(1):78–83. 10.1002/cncr.23518
27. Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, et al. Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 2021;384(9):829–841. 10.1056/NEJMoa2026982
28. Yuen A, Crandall B. Cardiovascular effects of tyrosine kinase inhibitors in patients with advanced renal cell carcinoma at the VA Sa n Diego healthcare system. Fed Pract. 2019;36(Suppl 3):S18–S24.
29. Ansari J, Alhelali S, Albinmousa Z, Farrag A, Ali AM, Abdelgelil M, et al. Rare case of intracardiac renal cell carcinoma metastasis with response to nivolumab: Case report and literature review. Case Rep Oncol. 2018;11(3):861–870. 10.1159/000495459
30. Cheng H, Force T. Why do kinase inhibitors cause cardiotoxicity and what can be done about it? Prog Cardiovasc Dis. 2010;53(2):114–120. 10.1016/j.pcad.2010.06.006
31. Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, et al. Efficacy and safety of nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma. Clin Cancer Res. 2021;27(1):78–86. 10.1158/1078-0432.CCR-20-2063
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May 25, 2022
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How to Cite
Renal Cell Carcinoma with Cardiac Metastases: A Case Report and Review of the Literature. (2022). Journal of Kidney Cancer, 9(2), 32-38. https://doi.org/10.15586/jkcvhl.v9i2.229
Section
Kidney Cancer: Case Reports
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How to Cite
Renal Cell Carcinoma with Cardiac Metastases: A Case Report and Review of the Literature. (2022). Journal of Kidney Cancer, 9(2), 32-38. https://doi.org/10.15586/jkcvhl.v9i2.229